ABSTRACT
AIM: To compare the changes of optic disc parameters, peripapillary retinal nerve fibers layer(pRNFL)thickness and macular ganglion cell layer(mGCL)thickness among patients with early diabetes retinopathy and healthy controls by Cirrus HD-optical coherence tomography(OCT).METHODS: In this cross-sectional comparative study, 45 non-diabetic retinopathy(NDR), 52 mild nonproliferative diabetic retinopathy(NPDR), 55 moderate NPDR with type 2 diabetes mellitus(T2DM)and 64 age-matched healthy controls were included. The fasting blood glucose(FBG), duration of diabetes, glycosylated hemoglobin(HbA1c)and past history of the patients were collected in detail. Optic disc parameters(i.e., binocular RNFL thickness symmetry percentage, rim area, optic disc area, cup-to-disc ratio, cup volume), pRNFL thickness and mGCL thickness were measured by Cirrus HD-OCT. The comparison of different groups was performed by one-way analysis of variance.RESULTS: Compared with the control group, the binocular RNFL thickness symmetry percentage and rim area were significantly decreased, while the average C/D and vertical C/D were significantly increased in the NDR group, mild NPDR group and moderate NPDR group(all P<0.05). Compared with the control group, the peripapillary RNFL thicknesses(superior, temporal, inferior, nasal)and macular GCL thickness(average, minimum, superior, supero-temporal, infero-temporal, inferior, supero-nasal, and infero-nasal)became thinner in the NDR group, mild NPDR group, and moderate NPDR group(all P<0.05).CONCLUSION: Patients with early DR have significantly decreased binocular RNFL thickness asymmetry, rim area, pRNFL and mGCL thickness, while they have significantly increased cup-to-disc ratio when compared to healthy controls. The results support the statement that DM causes inner retinal neurodegenerative changes even in T2DM patients without overt microangiopathy.
ABSTRACT
@#AIM: To quantitatively compare the effects of different surface treatments and designs of intraocular lens(IOL)on posterior capsule opacification(PCO)using EPCO2000.<p>METHODS: A retrospective study was conducted to observe 600(971 eyes)age-related cataract patients after 1a of phacoemulsification with implantation of intraocular lens in our hospital from March to November 2016. Patients were divided into 4 groups based on the type of IOL implant: 43 eyes in ZCB00 group, 365 eyes in ZA9003 group, 340 eyes in HQ-201HEP group and 223 eyes in Human Optics group. Retroillumination slit-lamp photographs were taken after the pupil was fully dilated and the degree of PCO was scored by EPCO2000 and compared among the groups.<p>RESULTS: There were 167 eyes(17.2%)with PCO involving the central 3mm of the pupil and 78 eyes(8.0%)with significant PCO or Nd:YAG laser capsulotomy. According to the hydrophobicity of IOL optical surface materials, the total score of hydrophobic group 0.000(0.000, 0.012)was obviously lower than that of hydrophilic group 0.127(0.056, 0.242)(<i>P</i><0.05). The total score of heparin-free group 0.127(0.056, 0.242)was lower than that of heparin-modified group 0.175(0.067, 0.371), and the difference was statistically significant(<i>P</i><0.05). The total score of single-piece group 0.000(0.000, 0.012)was obviously lower than that of three-piece group 0.120(0.041, 0.247)(<i>P</i><0.05). According to the different haptic angular magnitude of IOL, the total score of the 0° haptic anglulation group 0.107(0.000, 0.212)was lower than that of the 5° haptic anglulation group 0.142(0.051, 0.298), and the difference was statistically significant(<i>P</i><0.05).<p>CONCLUSION: A single-piece, square-edged, hydrophobic acrylic IOL can reduce PCO formation more effectively.